Associate Scientist II, Bioanalytical Sciences

Overview

Alnylam (Nasdaq: ALNY) is delivering on a bold vision to turn scientific possibility into reality, with a robust RNA interference (RNAi) therapeutics platform. As the pioneer in RNAi and the leading RNAi therapeutics company, we have always been uncompromisingly dedicated to translating the breakthrough science into transformational medicines to help as many people as possible. Long focused on rare and genetic diseases, our scientific advances are now allowing us to bring the power of RNAi therapeutics to more prevalent diseases and as a result, we are beginning to recognize the full potential of this new class of medicines.

Alnylam is committed to its journey to become a top 5 independent, global biopharma company. We are already admired and recognized for our dedication to patients, company culture that empowers people to do their best work, track record of scientific innovation, social responsibility, and commercial excellence.

Founded in 2002, and headquartered in Cambridge, Mass., Alnylam has over 1,650 employees at work across the globe. We are seeking smart, passionate, “change the world” kind of people who are ready to say, “challenge accepted” to our mission. Thanks to the commitment of every employee globally, Alnylam is proud to have been recognized as one of Fast Company’s 2021 Best Workplaces for Innovators, a Science Magazine Top Employer three years in a row (2019-2021), a Boston Globe Top Places to Work seven years in a row (2015-2021), a Great Place to Work in Asia, Japan, Brazil, the U.K., Germany, Spain, Netherlands, Italy, France and Switzerland, Seramount’s 100 Best Companies (formerly Working Mother 100 Best Companies) and Best Companies for Dads, Bloomberg’s Gender Equality Index two years in a row (2021-2022), among others. At Alnylam, we are committed to fostering a diverse, equitable and inclusive work environment, culture, and workforce, and we support several Employee Resource Networks.

The Bioanalytical Sciences group at Alnylam is seeking a highly motivated Associate Scientist II to join our team to help advance novel RNAi therapeutic programs from discovery to the clinic. The Bioanalytical Associate Scientist II will be responsible for executing biologically relevant assays to support early through late-stage drug development programs using techniques such as RT-qPCR, dPCR, and immunoprecipitation. They will execute assays and analyze results to evaluate PD and molecular biomarkers to advance RNAi therapeutic development. They will have strong interpersonal skills to work in a team environment, and to work with multiple investigative divisions to provide bioanalytical support. This is an exciting opportunity to join a vibrant team and interact with highly motivated scientists across a broad array of disciplinary expertise areas.

Summary of Key Responsibilities

• Evaluate gene expression and molecular PD biomarkers in biological matrices using techniques such as RT-qPCR, dPCR, or immunoprecipitation.
• Conduct sample analysis studies to support all of Alnylam’s RNAi therapeutic development from early to late stages.
• Perform RNA extraction.
• Design RT-qPCR primers and probes for target sequences.
• Execute experiments and perform data analysis. Create draft documents and presentations. Maintain an accurate laboratory notebook.
• Investigate areas for automation to increase quality or efficiency.

Qualifications

• Bachelor’s or Master’s degree (1-3 years of experience) in biology, biochemistry, chemistry, or relevant field.
• Hands on knowledge and technical skills to perform analytical methods such as qPCR and immunoprecipitation with subsequent data analysis.
• Previous experience working with oligonucleotides is strongly preferred.
• Previous experience with liquid handlers and automation is highly desirable.
• Familiar with Excel, Word, PowerPoint, and other analytical software (e.g. GraphPad Prism).
• Ability to multi-task and work in a fast-paced environment with minimal supervision.
• Excellent interpersonal skills and a team player.
• Experience with biofluids (e.g. serum) is strongly preferred.
• A quick learner with proven ability to perform in a fast-paced environment.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.